Discovering novel subsystems using comparative genomics

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Discovering novel subsystems using comparative genomics

MOTIVATION Key problems for computational genomics include discovering novel pathways in genome data, and discovering functional interaction partners for genes to define new members of partially elucidated pathways. RESULTS We propose a novel method for the discovery of subsystems from annotated genomes. For each gene pair, a score measuring the likelihood that the two genes belong to a same ...

متن کامل

Discovering regulatory motifs in the Plasmodium genome using comparative genomics

MOTIVATION Understanding gene regulation in Plasmodium, the causative agent of malaria, is an important step in deciphering its complex life cycle as well as leading to possible new targets for therapeutic applications. Very little is known about gene regulation in Plasmodium, and in particular, few regulatory elements have been identified. Such discovery has been significantly hampered by the ...

متن کامل

Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy

Chloroquine (CQ) and other quinoline-containing antimalarials are important drugs with many therapeutic benefits as well as adverse effects. However, the molecular targets underlying most such effects are largely unknown. By taking a novel functional genomics strategy, which employs a unique combination of genome-wide drug-gene synthetic lethality (DGSL), gene-gene synthetic lethality (GGSL), a...

متن کامل

Using PQ Trees for Comparative Genomics

Permutations on strings representing gene clusters on genomes have been studied earlier in [18, 14, 3, 12, 17] and the idea of a maximal permutation pattern was introduced in [12]. In this paper, we present a new tool for representation and detection of gene clusters in multiple genomes, using PQ trees [6]: this describes the inner structure and the relations between clusters succinctly, aids i...

متن کامل

Analysis of Staphylococcus using comparative genomics

These Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date. Over 1740 bacterial genome sequences are currently available in p...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bioinformatics

سال: 2011

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btr428